(A) Rheological parameters of blood

(B) Amount of a substance obtained orally and quantity of intakes

(C) Extent of absorption and hepatic first-pass effect 

(D) Glomerular filtration rate

(A) Plasma protein binding degree of substance

(B) Permeability through the brain-blood barrier

(c) Fraction of an uncharged drug reaching the systemic circulation following any route administration 

(D) Amount of a substance in urine relative to the initial doze

(A) Transport of drugs trough a membrane by means of diffusion

(B) Transport without energy consumption

(C) Engulf of drug by a cell membrane with a new vesicle formation

(D) Transport against concentration gradient (✓)

(A) Low ability to penetrate through the cell membrane lipids (✓)

(B) Penetrate through membranes by means of endocytosis

(C) Easy permeation through the blood-brain barrier

(D) High reabsorption in renal tubules

(A) Lipid-soluble

(B) Non-ionized substances

(C) Hydrophobic substances

(D) Hydrophilic substances 

(a) Active transport (carrier-mediated diffusion)

(B) Filtration (aqueous diffusion)

(C) Endocytosis and exocytosis

(D) Passive diffusion (lipid diffusion) (✓)

(A) Pharmacological effects of drugs

(B) Unwanted effects of drugs 

(C) Chemical structure of a medicinal agent

(D) Distribution of drugs in the organism

(A) The study of biological and therapeutic effects of drugs

(B) The study of absorption, distribution, metabolism and excretion of drugs 

(C) The study of mechanisms of drug action

(D) The study of methods of new drug development002. What does “pharmacokinetics” include?

(A) 2-3 half-lives
(B) 4-5 half-lives
(C) 6-7 half-lives
(D) 8-10 half-lives