All of the following concerning the blood-brain barrier (BBB) and the passage of drugs from the systemic circulation to cerebrospinal fluid (CSF) is true except

(A) ionized drugs are likely to cross into the CSF than unionized drugs
(B) the higher the lipid solubility of a drug, the more likely it will cross into the CSF
(C) inflammation of the meninges improves the likelihood that drugs will cross the BBB as compared to an uninflamed state

(D) None of These


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